For Inpatient Use
                  
How to Order Vistogard®
                  
                  IMPORTANT: Enroll patients in the Vistogard® Case Management
                    Program immediately after initiation of therapy to avoid potential treatment disruptions if the
                    patient is subsequently transferred to a non-inpatient setting. The Case Management Program is
                    administered by BioMatrix Specialty Pharmacy, the Specialty Pharmacy for Vistogard®.
                    Click the Case Management button below for additional details on the program from BioMatrix
                    Specialty Pharmacy.
                  
                  Case Management
                  Prescription Form
                 
               
             
          
          
            
              
                
                  For Outpatient Use
                  
To order Vistogard®
                  
                    - To order Vistogard® call 1-855-855-0708.
 
                    - Vistogard® is supplied exclusively through:
                      
                        - Specialty Distributor (for institutions with dispensing capabilities): Cardinal Health SPD*,
                          available 24 hours/day, 7 days/week
 
                        - Specialty Pharmacy: BioMatrix Specialty Pharmacy, Phone: 1-844-374-0604.,
                          Fax number: 1-844-374-0605.
 
                      
                     
                  
                  IMPORTANT: Enrollment of patients in the Case Management Program can
                    provide access to adherence support and/or assistance programs. Click the Case Management button
                    below for additional details on the program from BioMatrix Specialty Pharmacy.
                  
                  Case Management
                  Prescription Form
                 
               
             
          
          
            
              
                How Vistogard® (uridine triacetate) oral
                    granules is Supplied
                  
                    
                      
                        
                          | Name | 
                          NDC | 
                          Packets Per Carton | 
                          Strength | 
                          Form | 
                          SPD Item No. | 
                        
                      
                      
                        
                          | Vistogard® Full Course of Therapy | 
                          69468-151-20 | 
                          20 single-dose packets/carton | 
                          Each packet contains 10g of oral granules | 
                          Oral granules | 
                          5420443 | 
                        
                        
                          | Vistogard® 24-Hour Pack | 
                          69468-151-04 | 
                          4 single-dose packets/carton | 
                          Each packet contains 10g of oral granules | 
                          Oral granules | 
                          5420450 | 
                        
                      
                    
                    
               
              
              
                
                  
Vistogard Reimbursement
                  Please call us at 1-844-293-0007, Option 6 to
                    reach a reimbursement support specialist or email us at BTG@thepinnaclehealthgroup.com and your
                    inquiry will be routed to our reimbursement support team to assist you with your needs and any other
                    questions you may have.
                
               
             
          
          
         
        
        
        
        
        
        
          
            
            
              
              
                
                  
                    - Ma WW, Saif MW, El-Rayes, BF et al (2017), Emergency Use of
                      Uridine Triacetate for the Prevention and Treatment of Life-Threatening
                      5-Fluorouracil and Capecitabine Toxicity. Cancer 123(2):345-356
                    
 
                    - Ison G et al. (2016), FDA approval: Uridine triacetate for the treatment
                      ofpatients following fluorouracil or capecitabine overdose or exhibiting
                      early-onset severe toxicides following administration of these drugs. Clin
                      Cancer Res 22(18): 1-5
                    
 
                    - Brutcher E et al. (2018) Assessment and Treatment of Uncommon, Early-
                      onset, Severe Toxicides Associated With 5-Fluorouracil and
                      Capecitabine. Clin J Oncology Nursing 22 (6): 627-634
                    
 
                    - Polk A. et al. (2016). Incidence and risk factors for capecitabine-induced
                      symptomatic cardiotoxicity: A retrospective study o f452 consecutive
                      patients with metastatic breast cancer. BMJ Open, 6, e012798
                    
 
                    - ISMP (2007) Fluorouracil Incident Root Cause Analysis
                      Fluorouracil Error Ends Tragically, But Application of Lessons Learned Will Save
                        Lives | Institute For Safe Medication Practices (ismp.org)
                    
 
                    - Teva Parenteral Medicines, Inc. (2017). Adrucil® (fluorouracil injection,
                      solution) Package Insert
                    
 
                    - Genentech, Inc. (2016). Xeloda® (capecitabine) Package Insert
                    
 
                    - Meulendijks, D et al. (2016) Renal function, body surface area, and age
                      are associated with risk of early-onset fluoropyrimidine-associated
                      oxicity in patients treated with capecitabine-based anticancer regimens
                      in daily clinical care. European Journal of Cancer, 54, 120-130
                    
 
                    - Froehlich TK et al. (2015). Clinical importance of risk variants in the
                      dihydropyrimidine dehydrogenase gene for the prediction of early-onset
                      fluoropyrimidine toxicity. International Journal of Cancer, 136, 730-739
                    
 
                    - Mitani S et al. (2017) Acute hyperammonemic encephalopathy after
                      fluoropyrimidine-based chemotherapy: A case series and review of the
                      literature Medicine 96:22(e6874)
                    
 
                    - Etienne-Grimaldi M-C et al. (2017) New advances in DPYD genotype
                      and risk of severe toxicity under capecitabine. PLOS ONE, 12, e0175998
 
                    - Hamzic S et al. (2018) Come a long way, still a ways to go: from
                      predicting and preventing fluoropyrimidine toxicity to increased
                      efficacy? Pharmacogenomics 19(8):689-692 Published Online: 22 May
                      2018
 
                    - Rodriguez RU. Public teleconference regarding licensing and
                      collaborative research opportunities for: methods and compositions
                      relating to detecting dihydropyrimidine dehydrogenase (DPD). Fed
                      Regist. 2008; 73(129):38233
 
                    - Andre T et al. (2004) Oxaliplatin, fluorouracil, and leucovorin as
                      adjuvant treatment for colon cancer N Engl J Med. 2004;350: 2343-2351
 
                    - Sara JD et al. (2018) 5-fluorouracil and cardiotoxicity: a review
                      Therapeutic Advances in Medical Oncology Vol 10: 1-18
 
                    - Peng J et al. (2018) Cardiotoxicity of 5-fluorouracil and capecitabine in
                      Chinese patients: a prospective study Cancer Communications; 38(22):
                      1-7
 
                    - Yeh KH and Cheng AL (1997) High-dose 5-fluorouracil infusional
                      herapy is associated with hyperammonaemia, lactic acidosis and
                      encephalopathy Brit. J Cancer 75(3): 464-465
 
                    - Cordier P-Y et al. (2011). 5-FU-induced neurotoxicity in cancer patients
                      with profound DPD deficiency syndrome: A report of two cases. Cancer
                      Chemotherapy and Pharmacology, 68, 823-826
 
                    - BTG International Inc. (2023) Vistogard (uridine triacetate) Oral Granules Package Insert
 
                    - Garcia R et al. (2018) Prompt treatment with uridine triacetate improves
                      survival and reduces toxicity due to fluorouracil and capecitabine
                      overdose or dihydropyrimidine dehydrogenase deficiency Toxicology
                      and Applied Pharmacology 353 (2018) 67-73
 
                    - Baldeo C et al. (2018) Uridine triacetate for severe 5-fluorouracil
                      toxicity in a patient with thymidylate synthase gene variation: Potential
                      pharmacogenomic implications (Case Report). SAGE Open Medical
                      Case Reports Volume 6: 1-4
 
                    - Vaudo CE et al. (2016) Early-Onset 5-Fluorouracil Toxicity in a Patient
                      Negative for Dihydropyrimidine Dehydrogenase Mutations: The Clinical
                      Course of Reversal with Uridine Triacetate. Pharmacotherapy 36(11)
                      e178-e182
 
                    - Santos C et al. (2017) The successful treatment of 5-fluorouracil (5-FU)
                      overdose in a patient with malignancy and HIV/AIDS with uridine
                      triacetate. American Journal of Emergency Medicine 35(5) 802.e7-
                      802.e8
 
                    - Chu E (2014) Epidemiology and natural history of central venous access
                      device use and infusion pump function in the NO16966 trial Brit J Cancer
                      110, 1438-1445 doi: 10.1038/bjc
 
                  
                
               
              
             
           
         
        
          
            
            
              
              
                
                  
                    - Enroll patients as soon as Vistogard® is initiated by calling BioMatrix Specialty
                      Pharmacy at 1-844-374-0604.
 
                    - The Vistogard® Case Management Program is administered by BioMatrix Specialty
                      Pharmacy on behalf of BTG Pharmaceuticals
 
                    - Benefits of the Case Management Program include:
                      
                        - Facilitate a smooth pathway to transition patients from inpatient to outpatient care
 
                        - Delivery to the appropriate setting or to the patient’s home
 
                        - Provide instructions on dosing and administration
 
                        - Adherence calls once per day to ensure completion of the full 20-dose course of therapy (1
                          dose, every 6 hours, for 5 days)
 
                        - Assessment of eligibility for the Vistogard® Support Programs
                          
                            - Patient Assistance Program & Co-Pay Assistance
 
                          
                         
                      
                     
                    
                    - Prescription Form can be downloaded here.
 
                  
                
               
              
             
           
         
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