DON’T WAIT
TO ACT
VISTOGARD® (uridine triacetate)* is the first and only FDA-approved emergency treatment following 5-FU or capecitabine overdose, or early-onset, severe 5-FU or capecitabine toxicity1,2
*A pyrimidine analog.
Stay alert for early-onset, severe toxicity after 5-FU or capecitabine administration1,3
5-FU toxicity can be severe or even fatal4-6
These RED FLAGS require immediate attention3
Unusually severe side effects
Digestive
- Mucositis (mouth pain, pain on swallowing)6
- Vomiting not well controlled by antiemetics3,6
- Diarrhea6
Hematologic
- Leukopenia (WBC <3500 or falling rapidly)3,6
- Neutropenia (ANC <1000 cells/μL or falling rapidly)3,6,9
- Thrombocytopenia (<75,000 platelets/μ or falling rapidly)3,6
CNS and cardiac side effects
CNS
- Altered mental status1,6
- Cerebellar ataxia6,10
- Changes in cognition or consciousness1,6,10
Cardiac
- Acute cardiomyopathy1,3,6
- Chest pain1,3,6
- Heart failure1,3,6
- Heart attack1,3,6
- Irregular heartbeat1,3,6
Red flags occurring within 96 hours of 5-FU or capecitabine administration, particularly during the first or second treatment cycle, may indicate early-onset, severe toxicity requiring emergency treatment with VISTOGARD.11
5-FU = fluorouracil; ANC = absolute neutrophil count; CNS = central nervous system; WBC = white blood cells.
